Wei and colleagues for marginal single failure hazard rates, for hazard ratio parameter and for baseline hazard rate estimation. These methods specify Cox type semiparametric regression models for marginal single and double failure rates, and use estimating functions and empirical process methods, like those developed by Danyu Lin, L.J. Regression methods that adapt Cox regression to multivariate failure times, on the same or different failure time axes, will be presented.

Ross Prentice (Fred Hutchinson Cancer Research Center University of Washington) Our results generalise and formalise the method of dynamic path analysis (Fosen et al, 2006 Strohmaier et al, 2015) and also work by Lange and Hansen (2011). In the present talk, we demonstrate that combining the g-formula with the additive hazards model and a linear structural equation model for the mediator process results in simple and interpretable expressions for direct and indirect effects in terms of relative survival as well as cumulative hazards. In general, this leads to a version of the non-parametric g-formula (Robins, 1986). To define direct and indirect effects in a longitudinal survival setting we take an interventional approach (Didelez, 2018) where treatment is separated into one aspect affecting the mediator and a different aspect affecting survival. The emphasis is on a dynamic point of view, that is,understanding how the direct and indirect effects develop over time. We discuss causal mediation analyses for survival data and propose an approach based on the additive hazards model. Thursday, May 30, 2019, 9:00 am - 10:00 amĬausal inference is becoming an important theme in survival analysis. Semiparametric Regression Analysis of Interval-Censored Data Regression Models and Multivariate Life Tablesĭanyu Lin (University of North Carolina at Chapel Hill) Thursday, May 30, 2019, 9:00 am - 10:00 am Ross Prentice (Fred Hutchinson Cancer Research Center University of Washington) Aalen (University of Oslo, Norway)Ĭausal Inference for Survival Data, with Emphasis on Mediation Analysis

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